RESEARCH AND INNOVATION

Publications
and clinical studies

Scientific Rigour for Health and Wellbeing

Analysis, pharmaceutical experience, scientific safety: these are the foundations that support Giuliani's success.

The results of the Giuliani Research are shared with the national and international scientific community through numerous and qualified publications in specialist journals. Similarly, national and international conferences see the Pharmaceutical Company actively participating with original scientific contributions, through which it disseminates the results of its studies.

Publications 2021

D Pinto, A Trink, G Giuliani, F Rinaldi

ESDR291 - In vitro efficacy of a sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UVs damages

D Pinto, A Trink, G Giuliani, F Rinaldi, D Pinto, FM Calabrese, M De Angelis, G celano, Trink, G Giuliani, F Rinaldi. 50TH ANNUAL ESDR MEETING 2021.

ESDR339 - Lichen Planopilaris: The First Biopsy Layer Microbiota Inspection

M Altieri2 , A Passi3 , R Vezzali2 , D Pinto1 , G Giuliani1 and F Rinaldi1 1 R&D, GIULIANI SPA, Milan, Italy, 2 Nathura, Montecchio Emilia (RE), Italy and 3 Clinical Chemistry laboratory presso ASST dei Sette Laghi, University of Insubria, Varese, Italy. 50TH ANNUAL ESDR MEETING 2021. Sep 22-25, 2021

ESDR374- Characterization of a class IIb gynecological medical device containing hyaluronic acid, beta-glucan, sericin and glycerophosphoinositol: mechanism of action and pilot clinical experience (case report)

Daniela Pinto, Anna Trink, Giammaria Giuliani, Fabio Rinaldi

Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages

F Rinaldi, D Pinto, A Trink, G Giuliani, A Sparavigna. Clinical, Cosmetic and Investigational Dermatology 14, 501.

In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

F Rinaldi, D Pinto

Revisiting the Concept of “Angry Skin” and New “Calming” Strategies

P Filannino, R Di Cagno, O Vincentini, D Pinto, A Polo, F Maialetti, … Frontiers in Microbiology 12, 7

Nutrients bioaccessibility and anti-inflammatory features of fermented bee pollen: A comprehensive investigation

F Rinaldi, A Trink, G Giuliani, D Pinto. Dermatology and Therapy 11 (2), 339-345.

Italian survey for the evaluation of the effects of coronavirus disease 2019 (COVID-19) pandemic on alopecia areata recurrence

F Rinaldi, G Giuliani, F Rinaldi. Journal of Investigative Medicine, 1-2.

Importance of preserving the resident microflora of the skin to improve immunological response

D Pinto, T Ciardiello, M Franzoni, F Pasini, G Giuliani, F Rinaldi. Scientific Reports 11 (1), 1-7

Effect of commonly used cosmetic preservatives on skin resident microflora dynamics

G Babino, S Caccavale, D Pinto, A Trink, G Giuliani, F Rinaldi, … Dermatology and Therapy, 1-12

A Randomized Double-Blind Parallel-Group Study to Evaluate the Long-Term Effects of a Medical Device Containing 0.3% Octatrienoic Acid in the Treatment of Grade III Actinic …

F Rinaldi, A Trink, A Sparavigna, D Pinto. Journal of Biological Regulators and Homeostatic Agents 35 (2)

Photo-crosslinking of hyaluronic acid with low-level laser therapy device: a new combined and innovative approach

Publications 2020

Daniela Pinto, Francesco Maria Calabrese, Maria De Angelis, Giuseppe Celano, Giammaria Giuliani, Marco Gobbetti and Fabio Rinaldi

Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata

E Pontonio, M Verni, C Dingeo, E Diaz-de-Cerio, D Pinto, CG Rizzello. Antioxidants 9 (12), 1258

Impact of Enzymatic and Microbial Bioprocessing on Antioxidant Properties of Hemp (Cannabis sativa L.)

M Verni, E Pontonio, A Krona, S Jacob, D Pinto, F Rinaldi, V Verardo, …

Frontiers in microbiology 11, 1831

Bioprocessing of brewers’ spent grain enhances its antioxidant activity: Characterization of phenolic compounds and bioactive peptides

M Bertolini, J Chéret, D Pinto, N Hawkshaw, L Ponce, H Erdmann, …

The British Journal of Dermatology

A novel non-drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

F Rinaldi, A Trink, D Pinto

Dermatology and Therapy, 1-11

Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study

T Ciardiello, D Pinto, L Marotta, G Giuliani, F Rinaldi

Cosmetics 7 (2), 34

Effects of Fermented Oils on Alpha-Biodiversity and Relative Abundance of Cheek Resident Skin Microbiota

D Pinto, A Trink, E Sorbellini, G Giuliani, F Rinaldi

Journal of Investigative Medicine 68 (7), 1292-1294

‘Omics’ approaches for studying the microbiome in Alopecia areata

E Sorbellini, D Pinto, B Marzani, F Rinaldi

Dermatology and therapy 8 (2), 259-267

Drug Treatment for Androgenetic Alopecia: First Italian Questionnaire Survey on What Dermatologists Think about Finasteride

E Sorbellini, D Pinto, B Marzani, F Rinaldi Raffaella Gandolfi, Alessandro Contini, Daniela Pinto, Barbara Marzani, Stefano Pandini, Donatella Nava, Elena Pini

Chemistry & biodiversity 14 (12), e1700294

Synthesis and Biological Evaluation of New Natural Phenolic (2E,4E,6E)-Octa-2,4,6-trienoic Esters

P Daniela, M Barbara, S Elisabetta, R Fabio

Clinical & Experimental Dermatology and Therapies

Bovine Lactoferrin: A Nutritional Supplement for Down-Regulation of Inflammatory Response in Cutaneous Disorder

Publications 2019

D Pinto, E Sorbellini, B Marzani, M Rucco, G Giuliani, F Rinaldi

PloS one 14 (4)

Publications 2018

F Rinaldi, D Pinto, B Marzani, M Rucco, G Giuliani, E Sorbellini

J Transl Sci 4 (6), 2-4

A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

S Elisabetta, P Daniela, M Barbara, F Rinaldi

It is not invisible! A case report of 2 patients with scalp Lichen Planopilaris mimicking Androgenic Alopecia

E Borsani, LF Rodella, E Sorbellini, R Rezzani, D Pinto, B Marzani

Ann Pharmacol Pharm. 2017; 2 (20) 1107

Intraepidermal Injections of Autologous Epidermal Cell Suspension: A new promising approach to Dermatological Disorders. Preliminary Study

E Borsani, LF Rodella, E Sorbellini, R Rezzani, D Pinto, B Marzani

Ann Pharmacol Pharm. 2017; 2 (20) 1107

Intraepidermal Injections of Autologous Epidermal Cell Suspension: A New Promising Approach to Dermatological Disorders. Preliminary Study

Publications 2016

D Pinto, A Benedusi, F Rinaldi, B Marzani

Journal of Investigative Dermatology 136 (9), S183

In vitro biological activities of a cream designed for sensitive skin treatment

D Pinto, G Giuliani, B Marzani

Journal of Investigative Dermatology 136 (9), S196

Galeopsis segetum Necker extracts for the prevention and treatment of hair loss

Publications 2015

Y Ramot, B Marzani, D Pinto, JE Kloepper, R Paus

Archives of dermatological research 307 (9), 841-8

N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles

Publications 2012

B Marzani, D Pinto, F Minervini, M Calasso, R Di Cagno, G Giuliani, M Gobbetti, M De Angelis

Experimental dermatology 21 (9), 665-671

The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, β-defensin 2 and tumor necrosis factor-α genes

Publications 2011

B Marzani, D Pinto, M De Angelis, M Gobbetti, A Benedusi, G Giuliani

Journal of Investigative Dermatology 132, S12-S12

Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-β1, FGF7, VEGF-A and IL-8 genes

RESEARCH AND INNOVATION

Publications and clinical studies

Scientific Rigour for Health and Wellbeing

Analysis, pharmaceutical experience, scientific safety: these are the foundations that support Giuliani's success.

Publications 2021

ESDR291 - In vitro efficacy of a sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UVs damages

ESDR339 - Lichen Planopilaris: The First Biopsy Layer Microbiota Inspection

ESDR374- Characterization of a class IIb gynecological medical device containing hyaluronic acid, beta-glucan, sericin and glycerophosphoinositol: mechanism of action and pilot clinical experience (case report)

Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages

In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

Revisiting the Concept of “Angry Skin” and New “Calming” Strategies

Nutrients bioaccessibility and anti-inflammatory features of fermented bee pollen: A comprehensive investigation

Italian survey for the evaluation of the effects of coronavirus disease 2019 (COVID-19) pandemic on alopecia areata recurrence

Importance of preserving the resident microflora of the skin to improve immunological response

Effect of commonly used cosmetic preservatives on skin resident microflora dynamics

A Randomized Double-Blind Parallel-Group Study to Evaluate the Long-Term Effects of a Medical Device Containing 0.3% Octatrienoic Acid in the Treatment of Grade III Actinic …

Photo-crosslinking of hyaluronic acid with low-level laser therapy device: a new combined and innovative approach

Publications 2020

Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata

Impact of Enzymatic and Microbial Bioprocessing on Antioxidant Properties of Hemp (Cannabis sativa L.)

Bioprocessing of brewers’ spent grain enhances its antioxidant activity: Characterization of phenolic compounds and bioactive peptides

A novel non-drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study

Effects of Fermented Oils on Alpha-Biodiversity and Relative Abundance of Cheek Resident Skin Microbiota

‘Omics’ approaches for studying the microbiome in Alopecia areata

Drug Treatment for Androgenetic Alopecia: First Italian Questionnaire Survey on What Dermatologists Think about Finasteride

Synthesis and Biological Evaluation of New Natural Phenolic (2E,4E,6E)-Octa-2,4,6-trienoic Esters

Bovine Lactoferrin: A Nutritional Supplement for Down-Regulation of Inflammatory Response in Cutaneous Disorder

Publications 2019

Scalp bacterial shift in Alopecia areata

Diet and Microbiome Influence on Alopecia Areata: Experience from Case Reports

Increasing follicular resistance to bacterial contamination: A novel antimicrobial therapy?

Efficacy of a cosmetic product mimicking PRP in androgenetic alopecia

Publications 2018

Human microbiome: What’s new in scalp diseases

IL-17 inhibition: is it the long-awaited savior for alopecia areata?

New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies

Publications 2017

A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

It is not invisible! A case report of 2 patients with scalp Lichen Planopilaris mimicking Androgenic Alopecia

Intraepidermal Injections of Autologous Epidermal Cell Suspension: A new promising approach to Dermatological Disorders. Preliminary Study

Intraepidermal Injections of Autologous Epidermal Cell Suspension: A New Promising Approach to Dermatological Disorders. Preliminary Study

Publications 2016

In vitro biological activities of a cream designed for sensitive skin treatment

Galeopsis segetum Necker extracts for the prevention and treatment of hair loss

Publications 2015

N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles

Publications 2012

The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, β-defensin 2 and tumor necrosis factor-α genes

Publications 2011

Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-β1, FGF7, VEGF-A and IL-8 genes

Publications
and clinical studies